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Table 1 Associations between PODXL expression and EGFR expression, BRAF, KRAS mutations and MSI status in colorectal cancer

From: Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer

PODXL Cohort 1 p value Cohort 2 p value Cohort 3 p value
0 1 2 3 4 0 1 2 3 4 0 1 2 3 4
N (%) 268 (50.0) 186 (34.7) 10 (1.9) 71 (13.2) 1 (0.2)   137 (50.7) 67 (24.8) 31 (11.5) 25 (9.3) 0 (0.0)   197 (56.3) 65 (18.6) 29 (8.3) 22 (6.3) 3 (0.9)  
EGFR
 Low 225 (87.5) 141 (77.9) 7 (70.0) 34 (48.6) 0 (0.0) <0.001 106 (80.3) 55 (84.6) 22 (73.3) 12 (50.0) 0 (0.0) 0.008 171 (89.5) 55 (85.9) 21 (72.4) 10 (47.6) 0 (0.0) <0.001
 High 32 (12.5) 40 (22.1) 3 (30.0) 36 (51.4) 1 (100.0)   26 (19.7) 10 (15.4) 8 (26.7) 12 (50.0) 0 (0.0)   20 (10.5) 9 (14.1) 8 (27.6) 11 (52.4) 3 (100.0)  
 Missing 11 5   1    5 2 1 1    6 1   1   
BRAF status
 Wt 227 (90.8) 153 (85.5) 4 (40.0) 45 (70.3) 0 (0.0) <0.001 N/A N/A N/A N/A N/A   123 (89.8) 33 (78.6) 12 (60.0) 13 (81.3) 0 (0.0) <0.001
 Mutated 23 (9.2) 26 (14.5) 6 (60.0) 19 (29.7) 1 (100.0)   N/A N/A N/A N/A N/A   14 (10.2) 9 (21.4) 8 (40.0) 3 (18.7) 2 (100.0)  
 Missing 18 7   7          60 23 9 6 1  
KRAS status
 Wt 153 (61.0) 118 (65.9) 9 (90.0) 41 (64.1) 1 (100.0) 0.312 N/A N/A N/A N/A N/A   75 (58.1) 29 (70.7) 17 (85.0) 8 (57.1) 2 (100.0) 0.095
 Mutated 98 (39.0) 61 (34.1) 1 (10.0) 23 (35.9) 0 (0.0)   N/A N/A N/A N/A N/A   54 (41.9) 12 (29.3) 3 (15.0) 6 (42.9) 0 (0.0)  
 Missing 17 7   7          68 24 9 8 1  
MSI status
 MSS 227 (88.7) 146 (84.9) 0 (0.0) 52 (80.0) 1 (100.0) <0.001 N/A N/A N/A N/A N/A   170 (86.7) 51 (81.0) 20 (69.0) 22 (100.0) 2 (66.7) 0.021
 MSI 29 (11.3) 26 (15.1) 9 (100.0) 13 (20.0) 0 (0.0)   N/A N/A N/A N/A N/A   26 (13.3) 12 (19.0) 9 (31.0) 0 (0.0) 1 (33.3)  
 Missing 12 14 1 6          1 2