Fig. 1

Characterization of the PACC PDTX mouse model. a Hemotoxylin and eosin (H&E) staining of paraffin embedded patient and PDTX PACC tumor tissues (magnification X20) b Immunohistochemistry (IHC) of human specific antibodies, mitochondrial surface marker and lamin A+C. c IHC for acinar cell markers [amylase, lipase, Mist-1], acinar cell carcinoma markers [carcinoembryonic antigen (CEA), cytokeratin 18 (CK18), B-cell lymphoma/leukemia 10 (BCL10)], ducts [cytokeratin 19 (CK19)] and neuroendocrine markers [neuron specific enolase (NSE), chromogranin A (CgA)] at X20 magnification. Inlays are normal human pancreas