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Table 2 Correlation between FGFR expression and clinicopathological characteristics of cervical cancer

From: Expression of fibroblast growth factor receptor family members is associated with prognosis in early stage cervical cancer patients

  FGFR1 FGFR2 FGFR3 FGFR4
Mean histoscore [95 % CI] Mean histoscore [95 % CI] Mean histoscore [95 % CI] Mean histoscore [95 % CI]
Normal vs. cancer
 Normal 35 [27–42] 32 [23–40] 106 [89–124] 68 [57–80]
 Cancer 84 [77–91] 70 [64–77] 82 [76–87] 129 [122–136]
 P value <0.001 <0.001 0.02 <0.001
Stage
 IB1/IIA 82 [75–90] 72 [64–79] 83 [76–89] 130 [121–138]
 IB2/IIB 89 [70–107] 66 [48–83] 79 [65–93] 117 [97–136]
 P value 0.520 0.520 0.630 0.220
Cell type
 SCC 78 [71–86] 77 [69–85] 89 [82–96] 133 [124–141]
 AD/ASC 99 [83–115] 51 [40–62] 59 [48–71] 113 [98–128]
 P value 0.020 <0.001 <0.001 0.020
Tumor size
 ≤4 cm 85 [77–93] 74 [667–83] 83 [76–90] 131 [122–139]
 >4 cm 79 [64–91] 59 [47–70] 79 [68–89] 120 [105–134]
 P value 0.330 0.020 0.500 0.210
LVSI
 Negative 84 [75–93] 73 [64–82] 84 [76–93] 137 [127–147]
 Positive 82 [71–93] 67 [57–77] 78 [70–87] 114 [104–126]
 P value 0.770 0.390 0.330 0.004
Depth of invasion
 <50 % 88 [75–101] 73 [60–86] 85 [74–97] 132 [118–146]
 >50 % 81 [73–90] 70 [62–78] 80 [73–87] 126 [117–135]
 P value 0.420 0.670 0.490 0.470
LN metastasis
 Negative 83 [75–91] 74 [66–82] 84 [77–91] 132 [124–141]
 Positive 84 [70–98] 60 [48–72] 75 [65–83] 114 [98–129]
 P value 0.920 0.048 0.160 0.040
PM involvement
 Negative 85 [78–93] 73 [66–80] 83 [77–90] 129 [121–137]
 Positive 65 [48–82] 49 [34–64] 64 [50–78] 115 [91–139]
 P value 0.030 0.005 0.010 0.250
Resection margin
 Negative 83 [76–90] 71 [64–78] 82 [76–88] 128 [121–136]
 Positive 88 [50–127] 70 [42–99] 80 [52–108] 118 [75–161]
 P value 0.780 0.970 0.890 0.620
Primary treatment
 OP only 84 [74–94] 81 [70–91] 91 [81–100] 136 [125–147]
 OP + RT 81 [66–96] 67 [53–81] 73 [62–85] 127 [111–143]
 OP + CCRT 83 [70–96] 54 [45–64] 71 [62–81] 115 [100–129]
 Neoadjuvant 86 [2–171] 96 [17–175] 96 [20–173] 119 [38–199]
 P value 0.990 0.051 0.120 0.180
  1. FIGO International Federation of Gynecology and Obstetrics; SCC squamous cell carcinoma; Ag antigen; AD adenocarcinoma; ASC adenosquamous cell carcinoma; LVSI lymphovascular space invasion; LN lymph node; PM parametrium; OP operation; RT radiotherapy; CCRT concurrent chemoradiotherapy