Fig. 6
From: Lenalidomide normalizes tumor vessels in colorectal cancer improving chemotherapy activity
Lenalidomide is devoid of direct tumoricidal activity. Lenalidomide did not have direct cytotoxic activity against 4 different CRC cell lines in vitro (HCT116, LS513, SKCO-1 and LoVo). The panel reports data (mean ± SEM) relative to cytotoxic activity against HCT116 (a), SK-CO-1 (b), LS513 (c) and LoVo (d) (4 independent experiments, each with 10 replicates). The groups were compared with one-way ANOVA and post analysis comparisons (***) of each group to control vehicle and lenalidomide was carried out with Bonferroni post-test analysis. (***) P ≤ 0.001