Fig. 4

Vessel normalization by lenalidomide enhances chemotherapy activity. a The combination of lenalidomide and 5FU significantly delayed tumor growth. The experiments included 8 mice per group. Curves with mean tumor volume at each week are reported in the graph, the arrow indicates the start of treatments. The groups were compared with two-way ANOVA and post analysis comparisons at the end of treatment for each group versus control vehicle with Bonferroni post-test analysis. The percentage of tumor growth inhibition for each group of treatment compared to untreated controls is reported below the curves. b Representative histologic images (H&E staining) for each group of treatment. Combination of lenalidomide-5FU was associated with the restoration of tissue organization resembling physiologic colon structures