Fig. 1

Lenalidomide reduces mCRC vessel density. a Lenalidomide significantly reduced tumor vessel density, assessed by CD146 expression, in 5 mice with mCRC tumorgraft compared to the controls treated with irrelevant vehicle or 5FU (p = 0.0001). The cumulative values are presented as mean ± SEM of MOF, the groups were compared by one-way ANOVA. Post analysis comparisons of each group with the control vehicle was performed with Bonferroni post-test analysis (p < 0.05 for 5FU, p < 0.0001 for lenalidomide). b The pictures report representative IHC images of CD146 expression in the mice treated with lenalidomide and control vehicle. MOF, microscopic observation fields; (*), P ≤ 0.05; (**), P ≤ 0.01; (***), P ≤ 0.001; (****), P ≤ 0.0001