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Table 3 Selected signature mRNA expression of the PPAR signaling pathway through PCR assay in the left atria of mitral regurgitation patients with heart failure vs. normal control

From: Deciphering the gene expression profile of peroxisome proliferator-activated receptor signaling pathway in the left atria of patients with mitral regurgitation

Symbol Description Fold change P value
Lipid metabolism
 APOA1 Apolipoprotein A-I 21.724 0.005449
 HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 6.5229 0.083
 ACADM Acyl-CoA dehydrogenase, C-4 to C-12 straight chain 3.8861 0.031596
 FABP3 Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) 3.496 0.027634
 ETFDH Electron-transferring-flavoprotein dehydrogenase 3.4251 0.001157
 MLYCD Malonyl-CoA decarboxylase 3.372 0.000504
 ECH1 Enoyl CoA hydratase 1, peroxisomal 3.2082 0.006862
 CPT1B Carnitine palmitoyltransferase 1B 3.1846 0.0363
 CPT2 Carnitine palmitoyltransferase 2 3.1829 0.071083
 SLC27A6 Solute carrier family 27 (fatty acid transporter), member 6 3.0759 0.099593
 ACAA2 Acetyl-CoA acyltransferase 2 2.9113 0.005252
 EHHADH Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.8434 0.03971
 SLC27A1 Solute carrier family 27 (fatty acid transporter), member 1 2.8389 0.003705
 ACSL3 Acyl-CoA synthetase long-chain family member 3 2.2958 0.028469
 CPT1A Carnitine palmitoyltransferase 1A 1.9237 0.023573
 PLTP Phospholipid transfer protein 0.2311 0.027612
Coactivator
 SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 2.9058 0.037134
 PPARGC1B Peroxisome proliferator-activated receptor gamma, coactivator 1 beta 2.6275 0.080693
Signaling and stimulation of insulin
 SORBS1 Sorbin and SH3 domain containing 1 2.8643 0.03188
Transcription factor
 PPARA Peroxisome proliferator-activated receptor alpha 2.2651 0.026418
 KLF10 Kruppel-like factor 10 2.093 0.095046
Mediating protein–protein interactions
 FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.121 0.077129
Adipocyte differentiation
 MMP9 Matrix metallopeptidase 9 0.0737 0.081105