Peroxiredoxin 1 induces inflammatory cytokine response and predicts outcome of cardiogenic shock patients necessitating extracorporeal membrane oxygenation: an observational cohort study and translational approach

Table 2 Predictive values of peroxiredoxin 1 and cytokines for 7-day all cause mortality rate

Biomarkers	Cut-off (ng/mL)	AUC	SE	95 % CI	Sensitivity	Specificity	P value
0 h
Prdx1	759.09	0.734	0.092	0.56–0.91	0.692	0.774	0.015
CA IX	0.123	0.531	0.091	0.35–0.71	0.769	0.419	0.748
IL-6	0.839	0.618	0.112	0.40–0.84	0.462	0.903	0.222
IL-8	0.333	0.524	0.101	0.33–0.72	0.308	0.839	0.807
IL-10	0.245	0.526	0.103	0.32–0.73	0.308	0.903	0.787
MCP-1	0.211	0.618	0.098	0.43–0.81	0.615	0.677	0.222
TNF-α	0.0013	0.653	0.090	0.48–0.83	0.462	0.839	0.114
IL-1β	0.019	0.600	0.104	0.40–0.81	0.308	1.000	0.298
24 h
Prdx1	59.78	0.861	0.059	0.75–0.98	1.000	0.567	<0.001
Prdx1	1027.23	0.861	0.059	0.75–0.98	0.667	0.900	<0.001
CA IX	0.466	0.811	0.065	0.68–0.94	1.000	0.567	0.002
IL-6	0.984	0.883	0.062	0.75–1.00	0.750	0.900	<0.001
IL-8	0.208	0.881	0.064	0.75–1.00	0.917	0.800	<0.001
IL-10	0.083	0.861	0.071	0.72–1.00	0.917	0.767	<0.001
MCP-1	1.223	0.856	0.088	0.00–1.00	0.833	0.933	<0.001
TNF-α	0.0020	0.828	0.076	0.68–0.98	0.833	0.833	0.001
IL-1β	0.0043	0.736	0.081	0.58–0.90	0.667	0.700	0.018

Cut-off values are determined by receiver-operating characteristic (ROC) analysis
Prdx peroxiredoxin, CA carbonic anhydrase, IL interleukin, MCP monocyte chemotactic protein, TNF tumor necrosis factor, AUC area under the ROC curve, SE standard error, CI confidence interval

ISSN: 1479-5876