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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Peroxiredoxin 1 induces inflammatory cytokine response and predicts outcome of cardiogenic shock patients necessitating extracorporeal membrane oxygenation: an observational cohort study and translational approach

Fig. 5

Interaction of TLR4, CD14 and Prdx1 in cardiogenic shock patients who received ECMO support. Monocyte TLR4 (a) and CD14 (b) surface expressions [median and interquartile range of the mean fluorescence intensity (MFI) as assessed by flow cytometry analysis] at the indicated time points in 24 survivors (open boxes) and 9 deaths (grey boxes). c TLR4 expression on monocytes was found best correlated to the Prdx1 levels at 24 h after initiating ECMO support (correlation coefficient = 0.425, P = 0.015, indicated by solid circle and line). Similarly, plasma Prdx1 levels at 0 and 2 h were also noted to be positively related (indicated by dotted lines). d TLR4 and CD14 expressions were found positively correlated to each other at all the time points through the observation course within 24 h. The dotted lines indicated the linear fits for the correlation of both variables at each time point. Solid circles and line indicated 6 h after initiating ECMO support was the time point with the strongest correlation between TLR4 and CD14 expression on the monocytes of patients (correlation coefficient = 0.699, P < 0.001)

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