CTLA-4 polymorphisms and haplotype correlate with survival in ALL after allogeneic stem cell transplantation from related HLA-haplotype-mismatched donor

Table 4 Univariate analyses of the CTLA-4 SNP and haplotype on outcomes in ALL after HSCT

	−1661 AA/AG+GG	−318 CC/CT+TT	CT60 GG/GA+AA	+49 GG/GA+AA	With ACGG/ACGG	Without ACAA
Relapse
P	0.779	0.779	0.738	0.382	0.382	0.738
HR	0.875	0.875	0.864	0.692	0.692	0.864
95 % CI	0.344–2.223	0.344–2.223	0.366–2.041	0.303–1.580	0.303–1.580	0.366–2.041
DFS
P	0.575	0.575	0.666	0.240	0.240	0.666
HR	0.784	0.784	0.844	0.645	0.645	0.844
95 % CI	0.336–1.837	0.336–1.837	0.392–1.818	0.310–1.341	0.310–1.341	0.392–1.818
OS
P	0.373	0.373	0.101	0.022^#	0.022^#	0.101
HR	0.565	0.565	0.350	0.306	0.306	0.350
95 % CI	0.161–1.984	0.161–1.984	0.100–1.229	0.111–0.842	0.111–0.842	0.100–1.229
aGVHD III-IV
P	0.527	0.527	0.862	0.324	0.324	0.862
HR	0.030	0.030	0.809	0.299	0.299	0.809
95 % CI	0.000–1534.4	0.000–1534.4	0.073–8.917	0.027–3.294	0.027–3.294	0.073–8.917
Extensive cGVHD
P	0.516	0.516	0.045^#	0.273	0.273	0.045^#
HR	0.655	0.655	3.067	2.041	2.041	3.067
95 % CI	0.183–2.350	0.183–2.350	1.027-9.159	0.569–7.322	0.569–7.322	1.027–9.159

HR indicates hazard ratio, CI confidence interval, HSCT hematopoietic stem cell transplantation
^#P < 0.05

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