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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Autoantigen-specific immunosuppression with tolerogenic peripheral blood cells prevents relapses in a mouse model of relapsing-remitting multiple sclerosis

Fig. 3

Cytokine expression of peripheral lymphocytes from MICCop-treated EAE mice after in vitro-restimulation with PLP and Copaxone®. Splenocytes (SPCs; left column) and lymph node cells (LNCs; right column) were isolated from PBS- (control, black, n = 9) and MICCop-treated (MICCop, grey, n = 8) EAE mice and restimulated in vitro with 20 µg/mL PLP139-151 or Copaxone® (Cop). After 72 and 96 h, supernatants were collected and concentrations of TGF-β (a and b) and IL-10 (c and d) were determined by ELISA. Unstimulated cells represent basic cytokine expression. The mean ± standard error of the mean (SEM) was calculated for values measured in duplicate. Treatment groups were compared using unpaired Student’s t test (***p < 0.001; **p < 0.01; *p < 0.05; ns, not significant)

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