Fig. 2From: Metronomic temozolomide as second line treatment for metastatic poorly differentiated pancreatic neuroendocrine carcinomaPeritumoral lymphocytes and leucocytes infiltrating tumor microenviroment. Tumor-infiltrating CD8 + T cells (circles) have been detected in the pNEC tumor biopsy of the patient. These cells infiltrating tumor micro environment are frequently associated with favorable clinical outcome in a remarkably large spectrum of cancers as MCC and pNECBack to article page