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Table 4 Sensitivity and specificity of the 6 candidate microRNAs of 104 patients with UICC stage II–III colorectal cancer according to real-time quantitative PCR

From: Development of a deregulating microRNA panel for the detection of early relapse in postoperative colorectal cancer patients

microRNAs

AUCa (95 % CI)

Cut-offb value

Sensitivity (%)

Specificity (%)

Accuracyc (%)

miR-7

0.647 (0.543–0.739)

−0.37

53.1

80.0

66.7

miR-93

0.752 (0.658–0.832)

1.57

72.0

74.1

73.1

miR-141

0.617 (0.516–0.711)

0.59

76.9

52.6

72.8

miR-195

0.615 (0.514–0.710)

0.93

96.0

26.4

56.3

miR-494

0.634 (0.534–0.727)

3.05

42.9

85.2

61.2

let-7b

0.671 (0.567–0.764)

2.09

55.1

76.1

61.1

6-miR panel

0.834 (0.740–0.905)

2.00

76.6

71.4

77.4

Combined panel

0.948 (0.881–0.984)

4.00

89.4

88.9

89.1

  1. aArea under the ROC curve
  2. bThe optimal cut-off value for each microRNA was calculated by analyzing receiver-operating characteristic (ROC) curves, with the relative expression level of miR being normalized to U6b
  3. cAccuracy is defined as the proportion of samples correctly classified into early relapsed (true positives) or nonearly relapsed (true negatives) groups