Fig. 2

In vivo effect of Fn14-Fc on Ig production in SLE mice. Sanroque mice were injected intraperitoneally with Fn14-Fc (100 μg/mouse) or control-Fc (100 μg/mouse) (n = 5/group) for 3 weeks. Mice were sacrificed on day 21 after the first injection. The serum total IgG, IgG1 and IgG2a levels were determined by ELISA. Data are expressed as means ± SDs. *P < 0.05, **P < 0.01 compared to the control-Fc treated group