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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Preclinical exploration of combining plasmacytoid and myeloid dendritic cell vaccination with BRAF inhibition

Fig. 5

The presence of immune cells mitigates the inhibitory effects of vemurafenib on DC maturation and cytokine secretion. Freshly isolated PBMCs were cultured ex vivo and activated with R848 in presence or absence of 60 μg/ml vemurafenib. Graphs show the cell surface expression levels of CD80, CD86, CD40, and PD-L1 on pDCs (a) and mDCs (b) after 18 h. c Graphs show the levels of the cytokines IL-10, IL-6, TNFα, IL-1β, and IL-5 measured in the supernatant after 18 h. Shown is the mean (+SEM) of four independent experiments *P < 0.05, **P < 0.01, ***P < 0.001

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