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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Preclinical exploration of combining plasmacytoid and myeloid dendritic cell vaccination with BRAF inhibition

Fig. 2

Vemurafenib impairs maturation of ex vivo cultured pDCs and mDCs. Freshly isolated pDCs (a) and mDCs (b) were cultured ex vivo and activated with R848 in presence or absence of 60 μg/ml vemurafenib. Graphs show the cell surface expression levels of CD80, CD86, CD40, and PD-L1 after 18 h. Freshly isolated pDCs (c) and mDCs (d) were cultured ex vivo and activated with R848 in presence or absence of 60 μg/ml vemurafenib. Graphs show the levels of the cytokines IL-10, IL-6, TNFα and IFNα (only pDCs) measured in the supernatant after 18 h. Shown is the mean (+SEM) of six independent experiments *P < 0.05, **P < 0.01,***P < 0.001

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