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Table 5 Univariate analysis of the impact of epigenetic methylation-related protein expression on breast cancer patient prognosis by log-rank test

From: Differential expression of the epigenetic methylation-related protein DNMT1 by breast cancer molecular subtype and stromal histology

Parameter

Number of patients/recurrence/death

Disease-free survival

Overall survival

Mean survival (95 % CI) months

P value

Mean survival (95 % CI) months

P value

5-meC (T)

 Low

44/2/3

131 (124–138)

0.206

132 (124–141)

0.370

 High

304/30/32

126 (121–130)

127 (123–132)

5-meC (S)

 Low

14/1/1

129 (115–143)

0.709

131 (116–145)

0.659

 High

334/31/34

127 (122–131)

128 (124–132)

DNMT1 (T)

 Low

316/28/29

127 (123–131)

0.348

129 (126–133)

0.041

 High

23/4/6

115 (100–129)

111 (95–128)

DNMT1 (S)

 Negative

346/32/35

N/A

N/A

N/A

N/A

 Positive

2/0/0

N/A

N/A

ISL-1 (T)

 Negative

343/32/34

N/A

N/A

128 (124–132)

0.436

 Positive

5/0/1

N/A

63 (60–66)