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Table 4 Expression of epigenetic methylation-related proteins by stromal phenotype

From: Differential expression of the epigenetic methylation-related protein DNMT1 by breast cancer molecular subtype and stromal histology

Parameter

Total (n = 348) (%)

Desmoplastic type (n = 97) (%)

Inflammatory type (n = 30) (%)

Normal-like type (n = 16) (%)

Sclerotic type (n = 205) (%)

P value

5-meC (T)

 Low

44 (12.6)

8 (8.2)

2 (6.7)

0 (0.0)

34 (16.6)

0.049

 High

304 (87.4)

89 (91.8)

28 (93.3)

16 (100.0)

171 (83.4)

5-meC (S)

 Low

14 (4.0)

3 (3.1)

1 (3.3)

0 (0.0)

10 (4.9)

0.726

 High

334 (96.0)

94 (96.9)

29 (96.7)

16 (100.0)

195 (95.1)

DNMT1 (T)

 Low

316 (90.8)

88 (90.7)

21 (70.0)

14 (87.5)

193 (94.1)

<0.001

 High

32 (9.2)

9 (9.3)

9 (30.0)

2 (12.5)

12 (5.9)

DNMT1 (S)

 Negative

346 (99.4)

97 (100.0)

29 (96.7)

16 (100.0)

204 (99.5)

0.197

 Positive

2 (0.6)

0 (0.0)

1 (3.3)

0 (0.0)

1 (0.5)

ISL-1 (T)

 Negative

343 (98.6)

96 (99.0)

29 (96.7)

16 (100.0)

202 (98.5)

0.775

 Positive

5 (1.4)

1 (1.0)

1 (3.3)

0 (0.0)

3 (1.5)