Skip to main content

Table 3 Expression of epigenetic methylation-related proteins by breast cancer subtype

From: Differential expression of the epigenetic methylation-related protein DNMT1 by breast cancer molecular subtype and stromal histology

Parameter

Total (n = 348) (%)

Luminal A (n = 162) (%)

Luminal B (n = 84) (%)

HER-2 (n = 27) (%)

TNBC (n = 75) (%)

P value

5-meC (T)

 Low

44 (12.6)

27 (16.7)

8 (9.5)

3 (11.1)

6 (8.0)

0.200

 High

304 (87.4)

135 (83.3)

76 (90.5)

24 (88.9)

69 (92.0)

5-meC (S)

 Low

14 (4.0)

7 (4.3)

2 (2.4)

1 (3.7)

4 (5.3)

0.810

 High

334 (96.0)

155 (95.7)

82 (97.6)

26 (96.3)

71 (94.7)

DNMT1 (T)

 Low

316 (90.8)

161 (99.4)

77 (91.7)

24 (88.9)

54 (72.0)

<0.001

 High

32 (9.2)

1 (0.6)

7 (8.3)

3 (11.1)

21 (28.0)

DNMT1 (S)

 Negative

346 (99.4)

162 (100.0)

84 (100.0)

27 (100.0)

73 (97.3)

0.062

 Positive

2 (0.6)

0 (0.0)

0 (0.0)

0 (0.0)

2 (2.7)

ISL-1 (T)

 Negative

343 (98.6)

159 (98.1)

84 (100.0)

27 (100.0)

73 (97.3)

0.455

 Positive

5 (1.4)

3 (1.9)

0 (0.0)

0 (0.0)

2 (2.7)