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Table 4 Internal validation using a Bootstrap procedure with 1000 replications

From: Single nucleotide polymorphisms in apoptosis pathway are associated with response to imatinib therapy in chronic myeloid leukemia

Parameter Gene SNP ID Bootstrap p value (95 % CI)
MCR FAS rs2234978 0.138 (0.000–0.605)
CCR FAS rs2234978 0.187 (0.000–0.727)
MMR FASLG rs763110 0.065 (0.000–0.351)
FAS rs2234978 0.178 (0.000–0.762)
MR4.5 FAS rs1800682 0.497 (0.053–0.951)
FAS rs2234767 0.050 (0.000–0.221)*
FAS rs2234978 0.073 (0.000–0.345)
LOR APAF1 rs1439123 0.142 (0.000–0.749)
FAS rs2234767 0.169 (0.000–0.783)
TF CASP10 rs13006529 0.102 (0.000–0.563)
PFS FASLG rs763110 0.365 (0.003–0.992)
OS CASP10 rs13006529 0.162 (0.002–0.991)
FASLG rs763110 0.424 (0.017–0.994)
  1. MCR major cytogenetic response, CCR complete cytogenetic response, MMR major molecular response, MR4.5 complete molecular response, LOR loss of response, TF treatment failure, PFS progression free survival, OS overall survival, HNF4A hepatocyte nuclear factor 4, alpha, APAF1 apoptotic peptidase activating factor 1, FAS Fas cell surface death receptor, FASLG Fas ligand (TNF receptor superfamily member 6)
  2. * P ≤ 0.05