Single nucleotide polymorphisms in apoptosis pathway are associated with response to imatinib therapy in chronic myeloid leukemia

Table 4 Internal validation using a Bootstrap procedure with 1000 replications

Parameter	Gene	SNP ID	Bootstrap p value (95 % CI)
MCR	FAS	rs2234978	0.138 (0.000–0.605)
CCR	FAS	rs2234978	0.187 (0.000–0.727)
MMR	FASLG	rs763110	0.065 (0.000–0.351)
MMR	FAS	rs2234978	0.178 (0.000–0.762)
MR4.5	FAS	rs1800682	0.497 (0.053–0.951)
	FAS	rs2234767	0.050 (0.000–0.221)^*
	FAS	rs2234978	0.073 (0.000–0.345)
LOR	APAF1	rs1439123	0.142 (0.000–0.749)
LOR	FAS	rs2234767	0.169 (0.000–0.783)
TF	CASP10	rs13006529	0.102 (0.000–0.563)
PFS	FASLG	rs763110	0.365 (0.003–0.992)
OS	CASP10	rs13006529	0.162 (0.002–0.991)
OS	FASLG	rs763110	0.424 (0.017–0.994)

MCR major cytogenetic response, CCR complete cytogenetic response, MMR major molecular response, MR4.5 complete molecular response, LOR loss of response, TF treatment failure, PFS progression free survival, OS overall survival, HNF4A hepatocyte nuclear factor 4, alpha, APAF1 apoptotic peptidase activating factor 1, FAS Fas cell surface death receptor, FASLG Fas ligand (TNF receptor superfamily member 6)
* P ≤ 0.05

ISSN: 1479-5876