|
Gene
|
SNP ID
|
Referent genotype
|
Adverse genotype
|
MCR
|
CCR
|
MMR
|
MR4.5
|
LOR
|
TF
|
PFS
|
OS
|
|---|
|
APAF1
|
rs1439123
|
CC/CT
|
TT
|
0.803
|
0.393
|
0.233
|
0.085
|
0.011*
|
0.323
|
0.510
|
0.939
|
|
APAF1
|
rs2288713
|
GG/TG
|
TT
|
0.747
|
0.886
|
0.617
|
0.530
|
0.812
|
0.992
|
0.271
|
0.863
|
|
CASP10
|
rs13006529
|
AA/TA
|
TT
|
0.250
|
0.433
|
0.513
|
0.671
|
0.144
|
0.025*
|
0.311
|
0.019*
|
|
FASLG
|
rs763110
|
TT/TC
|
CC
|
0.414
|
0.186
|
0.017*
|
0.123
|
0.145
|
0.097
|
0.001**
|
0.020*
|
|
FAS
|
rs1800682
|
TT/TC
|
CC
|
0.871
|
0.354
|
0.251
|
0.032*
|
0.086
|
0.129
|
0.428
|
0.863
|
|
FAS
|
rs2229521
|
GG/GA
|
AA
|
0.856
|
0.688
|
0.748
|
0.863
|
0.600
|
0.384
|
0.600
|
0.685
|
|
FAS
|
rs2234767
|
GG/GA
|
AA
|
0.944
|
0.259
|
0.179
|
0.013*
|
0.034*
|
0.093
|
0.374
|
0.978
|
|
FAS
|
rs2234978
|
TT/TC
|
CC
|
0.026*
|
0.036*
|
0.050*
|
0.011*
|
0.379
|
0.089
|
0.409
|
0.535
|
-
SNP single nucleotide polymorphism, MCR major cytogenetic response, CCR complete cytogenetic response, MMR major molecular response, MR4.5 complete molecular response, LOR loss of response, TF treatment failure, PFS progression free survival, OS overall survival, APAF1 apoptotic peptidase activating factor 1, CASP10 caspase 10, FAS Fas cell surface death receptor, FASLG Fas ligand (TNF receptor superfamily member 6)
- ** p < 0.01/* p < 0.05
