Fig. 8

Schematic presentation of the ER Stress-signaling pathways involved in Hericium erinaceus mycelium and erinacine A suppressed MPP-induced apoptosis in N2a cells. Hericium erinaceus mycelium has neuroprotective potential through blocking oxidative stress MPTP-induced neuron damage and that erinacine A contribute to the protective action. The inhibition of effect of MPP on the ER stress triggering production of ROS activates IRE1a/TRAF2 complex formation and phosphorylation of JNK1/2, p38 and NF-kB pathways, which inhibits the Fas and Bax up-regulation and decreases an apoptosis cascade