Fig. 5

Expression of PRL-3 in primary tumors and lymph node metastasis in prostate cancer tissue samples. Immunohistochemistry staining of primary prostate cancer tumor (a—Patient 1–4) with corresponding metastases (b—Patient 1–4). 100× magnification H&E = Hematoxylin and eosin stain a Patient 1 Gleason pattern 3 and 4, Patient 2 Gleason pattern 4, Patient 3 Gleason pattern 3 and 4, and Patient 4 Gleason pattern 3 and 4. Patient 2, 3 and 4 also has histologically normal glands in the sample (arrowheads). IHC show PRL-3 expression in malignant glands, some histologically normal glands are also positive (green arrowhead), whereas others are negative (black arrowheads). b All corresponding lymph node metastases express PRL-3