Fig.Ā 5From: Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cellsAntileukemic effects of bortezomib on CML cells. a K562 and b AR230 cells were plated on methyl-cellulose with 1, 5 and 10Ā nm of bortezomib for 10Ā days. Cells were counted manually under the microscope. The bar graphs represent the percentage of myeloid colonies. The graph represents the mean of the two independent experiments *pĀ <Ā 0.05Back to article page