Fig. 6

Reactivation of CMV infection and peripheral interferon signature in an AAD patient. Anti-CMV IgG [(left y-axis AU/mL)] and IgM [right y-axis (ratio between optical density and cut-off value)] levels are here shown for one individual patient over a 12 year time period (the patient was diagnosed with AAD in the year 2000) (a). IgG values are positive for the entire period (all values are above the short stippled line) while two IgM measurements are positive (values above the long stippled line) from 2006 to 2007. In b the relative mRNA expression in isolated CD4⁺ T cells of the three selected ISGs, USP18, EIF2AK2 and CXCL10 previously reported in [32] is shown. The red symbols represent the same patient as in (a)