Fig. 2
From: Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
Endocrine actions of FGF15/19. In fed state, BAs stored in the gallbladder release into the intestine. FGF15/19 expression is induced in the ileum. Secreted FGF15/19 acts on FGFR/KLB receptor complexes via repress CYP7A1 decrease bile acid synthesis, to stimulate glycogen synthase (GS) activity and glycogen synthesis through inactivation of GSK3, and to repress gluconeogenesis by blocking the phosphorylation and activation of CREB