Fig. 1
From: Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
The mechanism of FGF15/19 and FGF21 receptor activation. a FGFR and KLB that are constitutively associated on the plasma membrane comprise the FGF15/19 and FGF21 receptor, but the receptor is silent without FGF15/19 and FGF21. b Once FGF15/19 and FGF21 come into the vicinity of the receptor, it associates with its receptor. FGF15/19 and FGF21 through its C-terminus bind to KLB, and via its N-terminal part to contact FGFR. Binding of FGF15/19 and FGF21 to FGFR and KLB triggers the receptor phosphorylation, followed by downstream signal transduction and cellular functional responses