Fig. 2

Expression of POMC in CRPS patients. a Relative expression of POMC mRNA in the blood of CRPS patients (n = 26) and healthy controls (n = 19). 18S was used as the normalizer gene. Statistical analysis was conducted using unpaired t-test. b Relative expression of POMC in the blood of CRPS patients prior to ketamine therapy (responders, n = 8; poor responders, n = 7) and healthy controls (n = 19). 18S was used as the normalizer.*p < 0.05 **p < 0.01. Statistical analysis was conducted using one-way ANOVA with Bonferroni multiple comparison test as post-Hoc test. c Changes in relative expression of POMC in the blood of CRPS patients in response to ketamine therapy (responders, n = 8; poor responders, n = 7). Data were normalized to 18S expression. **p < 0.01, ***p < 0.001. Statistical analysis was conducted using paired and unpaired t-test. For all panels, data represent mean ± SEM