Fig. 3
Post-challenge kinetics of S. Typhi-specific CD8+ T cell responses differs with clinical outcome. a Kinetics for a representative participant from each group (TD and NoTD) showing the production of cytokines/chemokines and expression of CD107a by CD8+ TEM following stimulation with S. Typhi-infected B-EBV cells at different time points after challenge. b Areas under the curve below baseline were measured until time of diagnosis and plotted against the baseline level of responses for each of the indicated biomarkers stimulated with S. Typhi-infected AEH cells (squares), S. Typhi-infected B-EBV cells (circles) or S. Typhi-infected blasts (triangles). Correlation analyses were performed using mixed effects models to account for multiple observations per person. *p < 0.05, **p < 0.01, ***p < 0.001