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Table 2 Comparison of Mutations identified in MPE primary cultures and PDX

From: Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity

  KRAS EGFR PIK3CA BRAF MET TP53 STK11
Exon19del T790 M
PE e/10
(p10)
87.9 %
p.Q61H
(c.183 A>C)
     31.6 %
p. T1010I
(c. 3029 C>T)
  
PE e/10
(PDX)
50.4 %
p.Q61H
(c.183 A>C)
   49.2 %
p.E545 K
(c.1633 G>A)
    44.5 %
p.Q37*
(c.109 C>T)
PE b/11
(p3)
     53.5 %
p.V600E
(c.1799 T>A)
   
PE b/11
(PDX)
  100 %
p.E746_A750del
(c.2235_2249del15)
15.2 %
p.T790 M
(c.2369 C>T)
    97.6 %
p.R248Q
(c.743 G>A)
 
PE g/11
(p6)
        
PE g/11
(PDX)
75.5 %
p.Q61H
(c.183 A>C)
   49.5 %
p.E545 K
(c.1633 G>A)
    77.7 %
p.Q37*
(c.109 C>T)
PE i/11
(p5)
37.2 %
p.Q61 K
(c.181 C>A)
      100 %
p.R175H
(c.524 G>A)
 
PE i/11
(PDX)
29.4 %
p.Q61 K
(c.181 C>A)
      100 %
p.R175H
(c.524 G>A)
 
PE n/11 (p3)         
PE n/11
(PDX)
27 %
p.Q61 K
(c.181 C>A)
      100 %
p.R175H
(c.524 G>A)
 
PE s/11
(p3)
  42 %
p.E746_A750del
(c.2235_2249del15)
15 %
p.T790 M
(c.2369 C>T)
    14.3 %
p.S241F
(c.722 C>T)
 
PE s/11
(PDX)
  100 %
p.E746_A750del
(c.2235_2249del15)
15.8 %
p.T790 M
(c.2369 C>T)
    94.7 %
p.R248Q
(c.743 G>A)
 
PE u/11
(p6)
  49 %
p.E746_A750del
(c.2235_2249del15)
11.3 %
p.T790 M
(c.2369 C>T)
     
PE u/11
(PDX)
  92 %
p.E746_A750del
(c.2235_2249del15)
11.8 %
p.T790 M
(c.2369 C>T)
    100 %
p.R248Q
(c.743 G>A)
 
PE v/11
(p2)
  57 %
p.E746_A750del
(c.2235_2249del15)
      
PE v/11
(PDX)
  87.5 %
p.E746_A750del
(c.2235_2249del15)
     93.5 %
p.R248Q
(c.743 G>A)
 
PE z/11 (p4)         
PE z/11
(PDX)
  100 %
p.E746_A750del
(c.2235_2249del15)
14.2 %
p.T790 M
(c.2369 C>T)
    98.8 %
p.R248Q
(c.743 G>A)
 
PE b/12
(p4)
100 %
p.Q61H
(c.183 A>C)
   49.1 %
p.E545 K
(c.1633 G>A)
    100 %
p.Q37*
(c.109 C>T)
PE b/12
(PDX)
65.7 %
p.Q61H
(c.183 A>C)
   49 %
p.E545 K
(c.1633 G>A)
    63 %
p.Q37*
(c.109 C>T)
  1. * nonsense mutation