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Table 1 Mutations identified in MPE primary cultures

From: Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity

 

KRAS

EGFR

PIK3CA

BRAF

MET

TP53

STK11

In vivo

Exon19del

T790 M

PE d/10

(p10)

46 %

p.G12V

(c. 35 G>T)

       

No

PE e/10

(p10)

87.9 %

p.Q61H

(c.183 A>C)

    

31.6 %

p. T1010I

(c. 3029 C>T)

  

Yes

PE b/11

(p3)

    

53.5 %

p.V600E

(c.1799 T>A)

   

Yes

PE g/11

(p6)

        

Yes

PE h/11

(p4)

43.1 %

p.G12D

(c. 35 G>A)

       

No

PE i/11

(p5)

37.2 %

p.Q61 K

(c.181 C>A)

     

100 %

p.R175H

(c.524 G>A)

 

Yes

PE n/11

(p3)

        

Yes

PE o/11

(p10)

98.8 %

p.Q61H

(c.183 A>T)

  

54.2 %

p.E545 K

(c.1633 G>A)

   

100 %

p.Q37*

(c.109 C>T)

No

PE p/11

(p7)

 

100 %

p.E746_A750del

(c.2235_2249del15)

17.2 %

p.T790 M

(c.2369 C>T)

   

100 %

p.R248Q

(c.743 G>A)

 

No

PE r/11

(p5)

 

47 %

p.E746_A750del

(c.2235_2249del15)

      

No

PE s/11

(p3)

 

42 %

p.E746_A750del

(c.2235_2249del15)

15 %

p.T790 M

(c.2369 C>T)

   

14.3 %

p.S241F

(c.722 C>T)

 

Yes

PE u/11

(p6)

 

49 %

p.E746_A750del

(c.2235_2249del15)

11.3 %

p.T790 M

(c.2369 C>T)

     

Yes

PE v/11

(p2)

 

57 %

p.E746_A750del

(c.2235_2249del15)

      

Yes

PE z/11

(p4)

        

Yes

PE b/12

(p4)

100 %

p.Q61H

(c.183 A>C)

  

49.1 %

p.E545 K

(c.1633 G>A)

   

100 %

p.Q37*

(c.109 C>T)

Yes

PE f/13

(p3)

        

No

  1. * nonsense mutation