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Table 1 Mutations identified in MPE primary cultures

From: Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity

  KRAS EGFR PIK3CA BRAF MET TP53 STK11 In vivo
Exon19del T790 M
PE d/10
(p10)
46 %
p.G12V
(c. 35 G>T)
        No
PE e/10
(p10)
87.9 %
p.Q61H
(c.183 A>C)
     31.6 %
p. T1010I
(c. 3029 C>T)
   Yes
PE b/11
(p3)
     53.5 %
p.V600E
(c.1799 T>A)
    Yes
PE g/11
(p6)
         Yes
PE h/11
(p4)
43.1 %
p.G12D
(c. 35 G>A)
        No
PE i/11
(p5)
37.2 %
p.Q61 K
(c.181 C>A)
      100 %
p.R175H
(c.524 G>A)
  Yes
PE n/11
(p3)
         Yes
PE o/11
(p10)
98.8 %
p.Q61H
(c.183 A>T)
   54.2 %
p.E545 K
(c.1633 G>A)
    100 %
p.Q37*
(c.109 C>T)
No
PE p/11
(p7)
  100 %
p.E746_A750del
(c.2235_2249del15)
17.2 %
p.T790 M
(c.2369 C>T)
    100 %
p.R248Q
(c.743 G>A)
  No
PE r/11
(p5)
  47 %
p.E746_A750del
(c.2235_2249del15)
       No
PE s/11
(p3)
  42 %
p.E746_A750del
(c.2235_2249del15)
15 %
p.T790 M
(c.2369 C>T)
    14.3 %
p.S241F
(c.722 C>T)
  Yes
PE u/11
(p6)
  49 %
p.E746_A750del
(c.2235_2249del15)
11.3 %
p.T790 M
(c.2369 C>T)
      Yes
PE v/11
(p2)
  57 %
p.E746_A750del
(c.2235_2249del15)
       Yes
PE z/11
(p4)
         Yes
PE b/12
(p4)
100 %
p.Q61H
(c.183 A>C)
   49.1 %
p.E545 K
(c.1633 G>A)
    100 %
p.Q37*
(c.109 C>T)
Yes
PE f/13
(p3)
         No
  1. * nonsense mutation