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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation

Fig. 3

Exacerbation of airway inflammation induced by dsRNA in mice with established experimental HDM-asthma. BALF total protein levels increased after allergen challenge alone (a, left). This increase was sustained during additional saline administration, and was further dose-dependently enhanced at exacerbation by dsRNA (a, right). The cell necrosis biomarker LDH (b) and the alarmin ATP (c) were increased in BALF only at exacerbation by the high-dose of dsRNA. The data are presented as mean ± SEM (n = 4–6 mice in each group), #p < 0.05 compared to saline control, while *p < 0.05 compared to HDM/saline control

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