Fig. 1

Study design involving dsRNA challenges to mice with established HDM-induced experimental asthma. Mice received three intranasal (i.n) challenges of HDM extract per week (or saline as control), during three weeks to establish allergic ‘asthma’. This was followed by an exacerbation phase achieved by additional i.n. administration of dsRNA (or saline as control) on three consecutive days (day 21–23). dsRNA was given either as low-dose (50 μg) or high-dose (100 μg) every 24 h. The mice were sacrificed, either 24 h after three weeks of HDM challenge or after the exacerbation phase, 24 h after the final dsRNA administration