Fig. 1

Kaplan–Meier analysis of the time to development of metastases of two groups (groups A and B) defined by the first break point of the hierarchical clustering of 60 GIST samples. GIST samples were analyzed using the individual AF-gene set (a), OVCA-gene set (b), RCC-gene set (c), and the combined gene set (d). The time to development of metastasis differed between groups A and B (a, p = 0.003; b, p < 0.001; c, p = 0.003; and d, p = 0.029). GIST samples were also analyzed by separating the samples into 3 well-separated clusters using the combined gene set (e, p < 0.001), and by identifying samples as “good” or “poor” prognosis by any 2 of the 3 gene sets as described in the text (f, p < 0.001)