Fig. 3

Matrix stiffness modulates cell responses to chemo-agents. a High throughput drug test models was setup in 48 well plate; b a schematic illustration of drug treatment and cell analysis schedule; c cells were more sensitive to chemo agent at competent state and less sensitive at dormant state. Grafts are plotted based on the percentage of survived cell counts over non-treated control after 72 h of 25 µM paclitaxel and 25 μM gemcitabine treatment and 96 h recovery. The statistical significance was performed by Tukey test (p < 0.05, *)