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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: From competency to dormancy: a 3D model to study cancer cells and drug responsiveness

Fig. 2

Positive and passive changes of environmental stiffness regulate cell proliferation rate. a MDA-MB-231 expressed more MMPs to cope with increased mechanical stress. Enzyme secretion from MDA-MB-231 cells embedded in different gels for 7 days and analyzed with zymography; b the cell states of dormancy and competency could be altered by re-embedding cells into different stiffness gels; c exogenous enzymatic digestion of gel matrix changed MDA-MB-231 proliferation rate in situ. Tukey test significance * represented p < 0.05 and ** represented p < 0.01

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