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Table 1 NBDHEX and MC3181 IC50 values for U-2OS and tumor cell lines of different histotypes

From: c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition

Cell line

NBDHEX (μM)

MC3181 (μM)

U-2OS

0.9 ± 0.1

1.1 ± 0.1

MM-B1

1.3 ± 0.1

1.6 ± 0.2

MCF-7

1.6 ± 0.1

1.5 ± 0.1

COLO 205

5.3 ± 0.4

6.5 ± 0.2

HT-29

11.0 ± 0.4

15.8 ± 0.8

  1. IC50 values (mean ± SEM, n ≥ 3) after 48 h of treatment with NBDs, as determined from cell viability dose–response curves