Fig. 2
MSC treatment suppresses inflammatory infiltration and down-regulates activated HSCs, inhibiting fiber deposition in CCl4-induced chronic liver fibrosis. a Sirius Red, b HE, and c PAS staining of liver sections from control and MSC-treated mice. d α-SMA immunofluorescence staining of liver sections shows a down-regulation of activated HSCs. e F4/80 immunofluorescence staining of liver sections from normal, control and MSCs-treated mice. f, g Fibrosis and necroinflammatory scores determined using the scoring system of Ishak [31]. h, i, j Quantification of PAS-positivity, α-SMA-positivity and F4/80-positivety. Data are shown as mean ± standard error of the mean of 10 random high-power fields per mouse. *P < 0.05; **P < 0.01; ***P < 0.001