Table 1 Clinical activity results
Cohort 1 (n = 3) | Cohort 2 (n = 8) | Cohort 3 (n = 6) | All (n = 17) | |
|---|---|---|---|---|
Objective response (confirmed, RECIST v1.1) | ||||
ORR, % (n) | 33 % (1) | 75 % (6) | 100 % (6) | 76 % (13) |
CR, % (n) | 33 % (1) | 12 % (1) | 17 % (1) | 18 % (3) |
PR, % (n) | 0 | 62 % (5) | 83 % (5) | 59 % (10) |
PFS | ||||
Median, mo (95 % CI) | 2.7 (1.7, 22.0) | 12.2 (4.6, NE) | NE (NE) | 12.2 (5.7–22.0) |
DOR | ||||
Median, mo (95 % CI) | 20.9 (NE) | 10.6 (4.9, NE) | NE (NE) | 20.9 (10.6, 20.9) |