Fig. 10
From: Colorectal cancer-derived microvesicles modulate differentiation of human monocytes to macrophages
Presentation of the hypothetical interactions of monocytes/macrophages with TMVs in the blood and in the tumour bed. Early contact of monocytes with TMVs resulting in M1/M2 mix polarization is schematically presented on the right. Late contact of macrophages with TMVs resulting in the induction of proinflammatory cells—left side. TMVs interactions with other immune cells as well as with tumour cells were omitted to simplify the scheme