Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study

Table 2 Abnormal functional connectivity of bilateral ACC in BQD individuals compared with healthy controls

Brain region	BA	Voxels	Maximal t value	MNI coordinates
Brain region	BA	Voxels	Maximal t value	X	Y	Z
Left ACC
Pons		61	5.23	−6	−27	−33
L. caudate		38	4.26	−12	3	12
L. thalamus		53	3.44	−6	−18	12
R. thalamus		51	3.37	9	−21	9
Midbrain		43	2.98	−6	−12	−12
Cerebellum posterior lobe		27	3.10	−42	−57	−36
vmPFC, ACC	47	424	−4.5	15	30	−9
L. precuneus	7	32	−3.68	−15	−57	57
L. parahippocampal/hypothalamus		33	−3.36	−12	0	−18
Right ACC
Pons		114	5.87	−6	−24	−36
L. caudate		43	4.90	−12	3	12
R. caudate		41	3.45	15	15	9
L. thalamus		117	3.95	−6	−18	12
R. thalamus		64	3.91	18	−9	6
Midbrain		88	4.18	6	−9	−9
L. cerebellum posterior lobe		49	4.07	−36	−66	−33
Cerebellum anterior lobe		62	3.87	6	−60	−30
R. cerebellum posterior lobe		53	3.73	30	−66	−36
mPFC, ACC	32.47	461	−4.47	18	27	−27
L. precuneus	7	24	−3.80	−15	−57	60
hypothalamus/parahippocampal_L		24	−3.35	3	0	−15

A corrected threshold of P < 0.01 determined by Monte Carlo simulation was taken as meaning that there was a significant difference between groups
L left, R right, mPFC medial prefrontal cortex, ACC anterior cingulate cortex, BA Brodmann’s area, MNI montreal neurological institute, x, y, z coordinates of primary peak locations in the MNI space

ISSN: 1479-5876