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Table 5 Biomarker performance of Multi-Array ® assay for bladder cancer detection in cohort #2

From: A multiplex immunoassay for the non-invasive detection of bladder cancer

Biomarker Area under the curve 95 % confidence interval No. of correctly predicted events No. of correctly predicted nonevents No. of nonevents predicted as events No. of events predicted as nonevents Sen. (%) Spec. (%) PPV (%) NPV (%)
IL8 0.8489 0.7948–0.9030 74 82 18 26 74.0 82.0 80.4 75.9
MMP9 0.7620 0.6971–0.8269 70 69 31 30 70.0 69.0 69.3 69.7
A1AT 0.7935 0.7316–0.8554 72 78 22 28 72.0 78.0 76.6 73.6
ANG 0.7603 0.6949–0.8257 45 95 5 55 45.0 95.0 90.0 63.3
VEGFA 0.7121 0.6412–0.7830 57 76 24 43 57.0 76.0 70.4 63.9
CA9 0.6885 0.6159–0.7611 53 77 23 47 53.0 77.0 69.7 62.1
MMP10 0.7507 0.6844–0.8170 50 88 12 50 50.0 88.0 80.6 63.8
APOE 0.7240 0.6543–0.7937 52 84 16 48 52.0 84.0 76.5 63.6
PAI1 0.8335 0.8173–0.9097 74 86 13 24 74.0 86.0 85.4 76.8
SDC1 0.6540 0.5787–0.7292 85 41 59 15 85.0 41.0 59.0 73.2 
10-biomarker combination 0.8880 0.8416–0.9344 85 81 19 15 85.0  81.0  81.7  84.4