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Table 3 Comparison of bladder cancer diagnostic biomarker performance in Multi-Array ® assay and commercial assays in cohort #1

From: A multiplex immunoassay for the non-invasive detection of bladder cancer

Biomarker Area under the curve of Multi-Array assay Area under the curve of commercial assays Difference P value
Commercial-Multi-Array 95 % confidence interval
IL-8 0.8673 0.9018 0.0345 (−0.0534, 0.1224) 0.442
MMP-9 0.8474 0.8443 −0.0031 (−0.0673, 0.0611) 0.924
A1AT 0.8443 0.8694 0.0251 (−0.0541, 0.1043) 0.535
Angiogenin 0.8109 0.7555 −0.0554 (−0.1503, 0.0395) 0.253
VEGF 0.6897 0.6228 −0.0669 (−0.2323, 0.0986) 0.428
CA-9 0.5705 0.6468 0.0763 (−0.0886, 0.2411) 0.364
MMP-10 0.7753 0.6792 −0.0961 (−0.2315, 0.0392) 0.164
APOE 0.7827 0.7043 −0.0784 (−0.2338, 0.0771) 0.323
PAI-1 0.8924 0.6740 −0.2184 (−0.3506, −0.0862) 0.001
Syndecan 0.5831 0.6301 0.0470 (−0.2118, 0.3058) 0.722
All 10 biomarkers 0.9258 0.9467 0.0209 (−0.0628, 0.1046) 0.625