Table 3 Comparison of bladder cancer diagnostic biomarker performance in Multi-Array ® assay and commercial assays in cohort #1
From: A multiplex immunoassay for the non-invasive detection of bladder cancer
Biomarker | Area under the curve of Multi-Array assay | Area under the curve of commercial assays | Difference | P value | |
|---|---|---|---|---|---|
Commercial-Multi-Array | 95 % confidence interval | ||||
IL-8 | 0.8673 | 0.9018 | 0.0345 | (−0.0534, 0.1224) | 0.442 |
MMP-9 | 0.8474 | 0.8443 | −0.0031 | (−0.0673, 0.0611) | 0.924 |
A1AT | 0.8443 | 0.8694 | 0.0251 | (−0.0541, 0.1043) | 0.535 |
Angiogenin | 0.8109 | 0.7555 | −0.0554 | (−0.1503, 0.0395) | 0.253 |
VEGF | 0.6897 | 0.6228 | −0.0669 | (−0.2323, 0.0986) | 0.428 |
CA-9 | 0.5705 | 0.6468 | 0.0763 | (−0.0886, 0.2411) | 0.364 |
MMP-10 | 0.7753 | 0.6792 | −0.0961 | (−0.2315, 0.0392) | 0.164 |
APOE | 0.7827 | 0.7043 | −0.0784 | (−0.2338, 0.0771) | 0.323 |
PAI-1 | 0.8924 | 0.6740 | −0.2184 | (−0.3506, −0.0862) | 0.001 |
Syndecan | 0.5831 | 0.6301 | 0.0470 | (−0.2118, 0.3058) | 0.722 |
All 10 biomarkers | 0.9258 | 0.9467 | 0.0209 | (−0.0628, 0.1046) | 0.625 |