Overexpression of HMGA2 promotes tongue cancer metastasis through EMT pathway

Table 2 Univariate and multivariate analysis of factors associated with disease-free survival of patients with TSCC

Variable	N	Univariable			Multivariable
Variable	N	HR	95 % CI	P	HR	95 % CI	P
Age
≤55	34	1
>55	26	0.615	0.234–1.617	0.324
Sex
Male	37	1			1
Female	23	0.317	0.128–0.784	0.013	0.790	0.649–2.175	0.649
Differentiation
Well	24	1			1
Moderate/poor	36	3.829	1.537–9.538	0.004	2.323	0.760–7.103	0.139
T stage
T1 + T2	33	1			1
T3 + T4	27	3.638	1.638–8.082	0.002	1.087	0.397–2.972	0.871
N status
N⁻	35	1			1
N⁺	25	7.706	3.206–18.522	0.000	1.501	0.4594–4.908	0.501
Clinical stage
I + II	23	1			1
III + IV	37	8.873	3.902–13.623	0.001	13.806	1.333–143.024	0.028
HMAG2 staining
Negative	23	1			1
Positive	37	14.779	3.431–63.665	0.000	5.785	1.066–31.391	0.042
Snail staining
Negative	35	1			1
Positive	25	3.819	1.738–8.393	0.001	0.976	0.280–3.402	0.970

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