Fig. 4

Defects treated with lnASCs-seeded scaffolds demonstrate significant collagen deposition. Calvarial defects were created in the parietal bone of nude mice. Histology was conducted 16 weeks post operatively. a Representative images of sections stained with aniline blue are shown. b Quantification of collagen deposition. Bars, ± SEM. **, P < 0.01, compared to untreated defects; ^##, P < 0.01, compared between defects treated with scaffold and scaffolds seeded with lnASCs. ^ΦΦ, P < 0.01, compared between defects treated with scaffolds seeded with lnASCs and obASCs