Fig. 7

MiR-483-3p decreases EPCs homing, thrombus recanalization and resolution. a Representative images of recruitment of GFP-positive EPCs in the deep venous thrombosis (×200). b Quantification of GFP-positive EPCs in thrombus sections. Data are expressed as mean ± SEM (n = 10, **P < 0.01 vs. EPCs/vector; ***P < 0.001 vs. EPCs/vector; ^###P < 0.001 vs. EPCs/miR-483-3p). c Hematoxylin and eosin (HE) staining of thrombus Sects. (200× magnification). T means thrombus and VW indicates venous wall. d Weight of the venous thrombi at day 7 post the transplantation. Data are expressed as mean ± SEM (n = 10, **P < 0.01 vs. blank control; ***P < 0.001 vs. blank control; ^##P < 0.01 vs. EPCs/vector). e Significantly increase of thrombus recanalization and resolution was found in rats transplanted with EPCs transfected with miR- 483-3p sponge compared to EPCs transfected miR-483-3p on Day 7. f The recanalization of thrombus was quantified with Image J software by the area ratio of contrast agent in vascular with thrombosis. Data are expressed as mean ± SEM (n = 10, **P < 0.01 vs. blank control; ***P < 0.001 vs. blank control). Comparison among multiple groups was performed by one-way ANOVA followed by Least Significant Difference test