Table 3 List of unique proteins identified in each group with >9 scans total

Present only in HFpEF symptomatic group

 NALP2

Q9NX02

NACHT, LRR and PYD domains-containing protein

 ZEP3

Q5T1R4

Transcription factor HIVEP3

 MET25

Q8N6Q8

Methyltransferase-like protein 25

 SCAF8

Q9UPN6

Protein SCAF8

 CC105

Q8IYK2

Coiled-coil domain-containing protein 105

 FILA

P20930

Filaggrin

 MEG11

A6BM72

Multiple epidermal growth factor-like domains protein 11

 F19A2

Q8N3H0

Protein FAM19A2

 GRM1

Q13255

Metabotropic glutamate receptor

 YP010

Q96M66

Putative uncharacterized protein FLJ32790

 PSMD4

P55036

26S proteasome non-ATPase regulatory subunit 4

 PCCA

P05165

Propionyl-CoA carboxylase alpha chain, mitochondrial

 TCPR2

O15040

Tectonin beta-propeller repeat-containing protein

 KPRP

Q5T749

Keratinocyte proline-rich protein

 GTPB5

Q9H4K7

GTP-binding protein 5

 CV031

O95567

Uncharacterized protein C22orf31

 TFB2 M

Q9H5Q4

Dimethyladenosine transferase 2, mitochondrial

 SPXN4

Q5MJ08

Sperm protein associated with the nucleus on the X chromosome N4

 PF21A

Q96BD5

PHD finger protein 21A

Present only in HFpEF asymptomatic group

 H2A1H

Q96KK5

Histone H2A type

 H2A3

Q7L7L0

Histone H2A type 3

 POK7

Q9QC07

HERV-K_1q23.3 provirus ancestral Pol protein

 CC127

Q96BQ5

Coiled-coil domain-containing protein 127

 CC85C

A6NKD9

Coiled-coil domain-containing protein 85C

 WDR75

Q8IWA0

WD repeat-containing protein 75

 CXCL3

P19876

C-X-C motif chemokine 3

 RGPS1

Q5JS13

Ras-specific guanine nucleotide-releasing factor RalGPS1

 CXCL2

P19875

C-X-C motif chemokine 2

 CHMP7

Q8WUX9

Charged multivesicular body protein 7

 CK2N2

Q96S95

Calcium/calmodulin-dependent protein kinase II inhibitor 2

 CHIT1

Q13231

Chitotriosidase-1

 NOX1

Q9Y5S8

NADPH oxidase 1

 RBY1C

P0DJD4

RNA-binding motif protein, Y chromosome, family 1 member C

 WFDC3

Q8IUB2

WAP four-disulfide core domain protein 3

 ABCBB

O95342

Bile salt export pump

 HHAT

Q5VTY9

Protein-cysteine N-palmitoyltransferase HHAT

 MID51

Q9NQG6

Mitochondrial dynamic protein MID51

 LMNB1

P20700

Lamin-B1

Present only in control group

 MY15B

Q96JP2

Putative unconventional myosin-XVB

 CC020

Q8ND61

Uncharacterized protein C3orf20

 MCTS1

Q9ULC4

Malignant T cell-amplified sequence 1

 KSR1

Q8IVT5

Kinase suppressor of Ras 1

 PRP6

O94906

Pre-mRNA-processing factor 6

 DDX59

Q5T1V6

Probable ATP-dependent RNA helicase DDX59

 AL1A3

P47895

Aldehyde dehydrogenase family 1 member A3

 PCCB

P05166

Propionyl-CoA carboxylase beta chain, mitochondrial

 HNRCL

O60812

Heterogeneous nuclear ribonucleoprotein C-like 1

 BIRC3

Q13489

Baculoviral IAP repeat-containing protein 3

 NDUF4

Q9P032

NADH dehydrogenase 1 alpha subcomplex assembly factor 4

 MIRO2

Q8IXI1

Mitochondrial Rho GTPase 2

Present in HFpEF symptomatic and HFpEF asymptomatic groups but not control group

 MBD5

Q9P267

Methyl-CpG-binding domain protein 5

 RRBP1

Q9P2E9

Ribosome-binding protein 1

 ZNF79

Q15937

Zinc finger protein 79

 DCNL5

Q9BTE7

DCN1-like protein 5

 RGS3

P49796

Regulator of G-protein signaling 3

 TMOD2

Q9NZR1

Tropomodulin-2

 MYO5B

Q9ULV0

Unconventional myosin-Vb

 SC24D

O94855

Protein transport protein Sec24D

 SHIP1

Q92835

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

 ASIC1

P78348

Acid-sensing ion channel 1

 DMXL1

Q9Y485

DmX-like protein 1

 RECQ1

P46063

ATP-dependent DNA helicase Q1

 LY10L

Q9H930

Nuclear body protein SP140-like protein

 MBNL1

Q9NR56

Muscleblind-like protein 1

 KCC2B

Q13554

Calcium/calmodulin-dependent protein kinase type II subunit beta

 LIPA3

O75145

Liprin-alpha-3

 CD109

Q6YHK3

CD109 antigen

 ZN141

Q15928

Zinc finger protein 141

 YTHD2

Q9Y5A9

YTH domain family protein 2

 PLCD

Q9NRZ5

1-acyl-sn-glycerol-3-phosphate acyltransferase delta

 KIFA3

Q92845

Kinesin-associated protein 3

 TRI25

Q14258

E3 ubiquitin/ISG15 ligase TRIM25

 ETUD1

Q7Z2Z2

Elongation factor Tu GTP-binding domain-containing protein 1

 CDN1B

P46527

Cyclin-dependent kinase inhibitor 1B

 CO4A4

P53420

Collagen alpha-4(IV) chain

 TEX35

Q5T0J7

Testis-expressed sequence 35 protein

 MUC16

Q8WXI7

Mucin-16

 NPIL2

A6NJ64

NPIP-like protein LOC729978

 IRF2

P14316

Interferon regulatory factor 2

 MK07

Q13164

Mitogen-activated protein kinase 7

 APOA

P08519

Apolipoprotein(a)

 HIBCH

Q6NVY1

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

 USH1C

Q9Y6N9

Harmonin

 GOG8O

A6NCC3

Golgin subfamily A member 8O

 NADE

Q6IA69

Glutamine-dependent NAD(+) synthetase

 MET17

Q9H7H0

Methyltransferase-like protein 17, mitochondrial

 PITH1

Q9GZP4

PITH domain-containing protein 1

 IL1R1

P14778

Interleukin-1 receptor type 1

 C1GLT

Q9NS00

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

 OR2L3

Q8NG85

Olfactory receptor 2L3

 KV122

P04430

Ig kappa chain V-I region BAN

 GG8L2

A6NP81

Golgin subfamily A member 8-like protein 2

 ZFYV1

Q9HBF4

Zinc finger FYVE domain-containing protein 1

 CJ076

Q5T2E6

UPF0668 protein C10orf76

 STAB 1

Q9NY15

Stabilin-1

 EHBP1

Q8NDI1

EH domain-binding protein 1

 ANR24

Q8TF21

Ankyrin repeat domain-containing protein 24

 FAHD1

Q6P587

Acylpyruvase FAHD1, mitochondrial

 IWS1

Q96ST2

Protein IWS1 homolog

 THAP2

Q9H0W7

THAP domain-containing protein 2

 FNIP1

Q8TF40

Folliculin-interacting protein 1

 STK16

O75716

Serine/threonine-protein kinase 16

 CXX1

O15255

CAAX box protein 1

 GOG8R

I6L899

Golgin subfamily A member 8R

 SRRT

Q9BXP5

Serrate RNA effector molecule homolog

 ZN611

Q8N823

Zinc finger protein 611

 MRE11

P49959

Double-strand break repair protein MRE11A

 LONM

P36776

Lon protease homolog, mitochondrial

 GOG8 N

F8WBI6

Golgin subfamily A member 8 N

 ALPK2

Q86TB3

Alpha-protein kinase 2

 EI2BG

Q9NR50

Translation initiation factor eIF-2B subunit gamma

 NBPFL

A6NDD8

Neuroblastoma breakpoint family member 21

 ETV7

Q9Y603

Transcription factor ETV7