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Table 3 Analysis of associations between ME/CFS symptoms and mtDNA haplogroups

From: Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome

Haplogroup

Phenotype

Haplogroup average

Non haplogroup average

p value

q value*

HgJ

Joint pain, frequency

1.08

2.17

0.00835

0.04177

HgJ

Joint pain, severity

1.00

1.96

0.00460

0.02300

HgJ

Joint pain, distress

2.33

5.83

0.00828

0.04144

HgU

Bloating, severity

0.82

1.43

0.00996

0.04982

HgU

Bloating, distress

1.50

3.66

0.00925

0.04626

HgH

"Feeling dead" after exercise, frequency

3.01

2.66

0.00779

0.03895

  1. Haplogroup average describes the average phenotype value of all individuals within the given haplogroup
  2. *q values were calculated using the Benjamini–Hochberg method for correcting for multiple testing of haplogroups. A higher phenotype value indicates higher frequency/severity. All significant phenotypes listed here were assessed using the DSQ and only include ME/CFS individuals