Fig. 7

Baseline differences in overall phosphorylation of ERK1/2 in normal versus tumor tissue. The scatter plot (a) displays the fold change for individual patients, normalized to NC4 N0, and the mean with standard deviation is indicated. Representative spectra for ERK1/2 in normal and tumor tissue are shown in b, indicating the significantly increased abundance of ppERK1 in normal tissue, compared with tumor tissue. Kruskal–Wallis test and Dunn test for multiple comparisons or analysis of variance (ANOVA) were used for statistical analysis. N normal tissue, T tumor tissue; ^a p ≤ 0.05