Table 3 Change in biomarkers on treatment
| Â | Transformation | Trend | Estimates based on the model | p value (not corrected) | Bonferroni adjusted p value | ||||
|---|---|---|---|---|---|---|---|---|---|
Baseline | Week 6 | Week 12 | Week 18 | Week 24 | |||||
Hypoxia-related makers | |||||||||
 CA9 | Square root | Increase | 8.39 | 13.77 | 15.43 | 17.22 | 13.96 | 0 | <0.0001 |
 Clusterin | Log | 5.08 | 5.29 | 5.18 | 5.24 | 5.49 | 0.00042 | 0.0088 | |
 GLUT1 | Log | No significant change | 3.9 | 3.86 | 3.87 | 3.87 | 3.77 | 0.013 | 0.35 |
 Caveolin | Square root | 2.65 | 2.51 | 2.55 | 2.53 | 2.27 | 0.55 | >0.99 | |
 OPN | Log | 4.43 | 4.23 | 4.18 | 4.25 | 4.49 | 0.27 | >0.99 | |
Signaling pathways | |||||||||
 VEGFA | Log | Increase | 3.82 | 4.94 | 4.96 | 4.98 | 4.7 | 0 | <0.0001 |
 FLT3L | Log | 5.31 | 6.62 | 6.78 | 6.51 | 6.41 | 0 | <0.0001 | |
 AXL | None | 5452.58 | 7689.79 | 7603.41 | 7055.92 | 7348.19 | 0 | <0.0001 | |
 Gas6 | Square root | 38.54 | 55.03 | 50.85 | 45.67 | 52.88 | 0 | <0.0001 | |
 c-MET | None | 106.04 | 147.79 | 142.02 | 124.13 | 155.28 | 7.8E-09 | <0.0001 | |
 VEGFR | Log | Decrease | 7.32 | 6.66 | 6.37 | 6.37 | 7.02 | 1.7E-12 | <0.0001 |
 FLT3 | Log | No significant change | 3.98 | 3.71 | 3.75 | 3.91 | 3.84 | 0.003 | 0.081 |
 SCF | Log | 4.45 | 4.36 | 4.3 | 4.19 | 4.72 | 0.071 | >0.99 | |
IGF1R | Log | 5.43 | 5.58 | 5.6 | 5.64 | 5.57 | 0.035 | 0.95 | |
 IGFI | None | 48,276.42 | 49,765.76 | 38,327.24 | 46,418.15 | 47,612.38 | 0.034 | 0.92 | |
 IGFII | None | 149.85 | 168.03 | 151.46 | 147.71 | 146.22 | 0.34 | >0.99 | |
 HGF | Square root | 22.19 | 18.72 | 19.45 | 18.37 | 22.34 | 0.06 | >0.99 | |
Inflammation | |||||||||
 CRP | Square root | No significant change | 91.13 | 89.21 | 89.95 | 94.68 | 75.03 | 0.83 | >0.99 |
 IL6 | Log | 2.93 | 2.9 | 2.95 | 2.97 | 2.99 | 0.98 | >0.99 | |
Bone-related markers | Â | ||||||||
 BSAP | None | Increase | 153.54 | 179.84 | 175.52 | 141.5 | 164.09 | 0.00024 | 0.0065 |
 Trap5b | Log | Decrease | 1.44 | 1.16 | 1.2 | 1.16 | 1.31 | 0.00002 | 0.0005 |
 SEMA3C | Log | No significant change | 4.23 | 4.45 | 4.35 | 3.78 | 3.8 | 0.22 | >0.99 |
Micro-environment/angiogenesis | |||||||||
 IL8 | Log | Increase | 2.18 | 2.49 | 2.68 | 2.68 | 2.78 | 1.5E-12 | <0.0001 |
 ANG2 | Log | Decrease | 6.95 | 6.47 | 6.48 | 6.6 | 6.3 | 2.5E-08 | <0.0001 |
 TIMP2 | None | 72.28 | 65.65 | 66.34 | 65.08 | 62.28 | 1.2E-06 | <0.0001 | |
 TIE2 | Log | 8.62 | 8.25 | 8.1 | 7.89 | 8.43 | 0.00002 | 0.0005 | |
 Thrombo spondin | Square root | No significant change | 64.49 | 61.72 | 64.22 | 49.68 | 71.9 | 0.055 | >0.99 |