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Table 3 Change in biomarkers on treatment

From: Changes in plasma biomarkers following treatment with cabozantinib in metastatic castration-resistant prostate cancer: a post hoc analysis of an extension cohort of a phase II trial

  Transformation Trend Estimates based on the model p value (not corrected) Bonferroni adjusted p value
Baseline Week 6 Week 12 Week 18 Week 24
Hypoxia-related makers
 CA9 Square root Increase 8.39 13.77 15.43 17.22 13.96 0 <0.0001
 Clusterin Log 5.08 5.29 5.18 5.24 5.49 0.00042 0.0088
 GLUT1 Log No significant change 3.9 3.86 3.87 3.87 3.77 0.013 0.35
 Caveolin Square root 2.65 2.51 2.55 2.53 2.27 0.55 >0.99
 OPN Log 4.43 4.23 4.18 4.25 4.49 0.27 >0.99
Signaling pathways
 VEGFA Log Increase 3.82 4.94 4.96 4.98 4.7 0 <0.0001
 FLT3L Log 5.31 6.62 6.78 6.51 6.41 0 <0.0001
 AXL None 5452.58 7689.79 7603.41 7055.92 7348.19 0 <0.0001
 Gas6 Square root 38.54 55.03 50.85 45.67 52.88 0 <0.0001
 c-MET None 106.04 147.79 142.02 124.13 155.28 7.8E-09 <0.0001
 VEGFR Log Decrease 7.32 6.66 6.37 6.37 7.02 1.7E-12 <0.0001
 FLT3 Log No significant change 3.98 3.71 3.75 3.91 3.84 0.003 0.081
 SCF Log 4.45 4.36 4.3 4.19 4.72 0.071 >0.99
IGF1R Log 5.43 5.58 5.6 5.64 5.57 0.035 0.95
 IGFI None 48,276.42 49,765.76 38,327.24 46,418.15 47,612.38 0.034 0.92
 IGFII None 149.85 168.03 151.46 147.71 146.22 0.34 >0.99
 HGF Square root 22.19 18.72 19.45 18.37 22.34 0.06 >0.99
Inflammation
 CRP Square root No significant change 91.13 89.21 89.95 94.68 75.03 0.83 >0.99
 IL6 Log 2.93 2.9 2.95 2.97 2.99 0.98 >0.99
Bone-related markers  
 BSAP None Increase 153.54 179.84 175.52 141.5 164.09 0.00024 0.0065
 Trap5b Log Decrease 1.44 1.16 1.2 1.16 1.31 0.00002 0.0005
 SEMA3C Log No significant change 4.23 4.45 4.35 3.78 3.8 0.22 >0.99
Micro-environment/angiogenesis
 IL8 Log Increase 2.18 2.49 2.68 2.68 2.78 1.5E-12 <0.0001
 ANG2 Log Decrease 6.95 6.47 6.48 6.6 6.3 2.5E-08 <0.0001
 TIMP2 None 72.28 65.65 66.34 65.08 62.28 1.2E-06 <0.0001
 TIE2 Log 8.62 8.25 8.1 7.89 8.43 0.00002 0.0005
 Thrombo spondin Square root No significant change 64.49 61.72 64.22 49.68 71.9 0.055 >0.99